Curriculum Vitae Prof. Luca Scorrano

He received his MD in 1996 and his PhD in 2001 from University of Padova Medical School. In 2000, he moved to Boston, for his postdoctoral fellowship in the lab of the late S.J. Korsmeyer (Harvard Medical School). There he discovered the process of “cristae remodelling” that is required for the progression of apoptosis. His studies changed the common tenet that mitochondrial morphology remains untouched during apoptosis. In 2003 he was recruited by the DTI as Assistant Scientist, the lab has been interested in the role of mitochondrial morphology and of “mitochondria-shaping” proteins in health and genetic diseases. They discovered that Opa1 mutated in dominant optic atrophy has genetically distinguishable functions in mitochondrial fusion and in cristae remodelling and apoptosis; identified calcineurin as a trigger of mitochondrial fission, responsible for fragmentation, cristae remodelling and cell death in Huntington’s disease; discovered that Mitofusin (Mfn) 2 represents the long sought link between mitochondria and ER and that mitochondria elongate to evade autophagy during limited nutrient availability. He has been awarded the Eppendorf European Young Investigator Award, as well as several national Awards, and he was elected EMBO Young Investigator in 2006 and became EMBO Member in 2012. In 2007 he was promoted to Senior Telethon Scientist and recruited as Full Professor by the Dept. of Cell Physiology and Medicine of the University of Geneva Medical School (Switzerland). He also joined the Editorial Board of several prestigious journals like The EMBO Journal in 2009.

Honors

2013 2013 ESCI Award for Excellence in Basic/Translational Research, European Society for Clinical Investigation
2012 Elected EMBO Member
Chair, Keystone Symposium “Mitochondrial Dynamics and Physiology” Banff (Canada)
2011 “Chiara D’Onofrio” Prize, The D’Onofrio Foundation
ERC Starting grant (Consolidator)
2006 Eppendorf European Young Investigator Award, Eppendorf-Nature
EMBO Young Investigator
2005 “Angelo Minich” Prize for Medicine, Venetian Institute of Science, Letter and Arts
Rotary Prize for Science, Rotary Padova (Italy)
2004 Career Development Award, HFSP
2003 “AICC-Onlus” Prize, Italian Association of Cell Culture (AICC)
2001 “G. Capozza” Prize, Italian Group of Bioenergetics and Biomembranes (GIBB)

10 papers of the 10 last years

S. Cipolat*, T. Rudka*, D. Hartmann*, V. Costa, L. Serneels, K. Craessaerts, K. Metzger, C. Frezza, W. Annaert, L. D’Adamio, C. Derks, T. Dejaegere, L. Pellegrini, R. D’Hooge, and L. Scorrano‡, B. De Strooper‡. ‡corresponding authors. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling. Cell 126:163-75 (2006)
• Comment in: E. Gottlieb. OPA1 and PARL Keep a Lid on Apoptosis. Cell 126:27-9 (2006).
• Comment in: P. Delivani and S.J. Martin Mitochondrial membrane remodeling in apoptosis: an inside story Cell Death and Differentiation 13: 2007-10 (2006).
• Comment in: In brief, Nature Reviews Molecular and Cellular Biology 7:625
• FFa 6 Faculty of1000 Biology, B. Conradt

C. Frezza, S. Cipolat, O. Martins de Brito, M. Micaroni, G.V. Beznoussenko, T. Rudka, D. Bartoli, R.S. Polishuck, N.N. Danial, B. De Strooper and L. Scorrano. OPA1 Controls Mitochondrial Cristae Remodelling Independently from Mitochondrial Fusion During Apoptosis. Cell 126:176-89 (2006)
• Comment in: E. Gottlieb. OPA1 and PARL Keep a Lid on Apoptosis. Cell 126:27-9 (2006).
• Comment in: P. Delivani and S.J. Martin Mitochondrial membrane remodeling in apoptosis: an inside story Cell Death and Differentiation 13: 2007-10 (2006).
• FFa 9, Faculty of1000 Biology, B. Conradt and D. Xue

G.M. Cereghetti, A. Stangherlin, O. Martins de Brito, C.R. Chang, C. Blackstone, P. Bernardi and L. Scorrano Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl. Acad. Sci. USA. 105:15803-15808 (2008).

O. Martins de Brito and L. Scorrano Mitofusin 2 tethers mitochondria and endoplasmic reticulum. Nature 456:605-10 (2008).
• Comment in: K. Merkwirth and T. Langer. Mitofusin 2 builds a bridge between ER and mitochondria. Cell 135:1165-7 (2008).
• Comment in: A. Parekh. Calcium signalling: mitofusins promote interorganellar crosstalk. Curr Biol. 19:R200-3. (2009)
• Comment in: In brief, Nature Reviews Molecular and Cellular Biology 10:5
• FFa 15, Faculty of1000 Biology, T Frey/Y. Yamashita/H. Osiewacz/D. Green
• FFa 8, Faculty of1000 Medicine, N. Bresolin

V. Costa, M Giacomello, R. Hudec, R. Lopreiato, G. Ermak, D. Lim, W. Malorni, K.J.A. Davies, E. Carafoli, and L. Scorrano Mitochondrial fission and cristae disruption increase the response of cell models of Huntington’s disease to apoptotic stimuli EMBO Mol. Med. 2:490-503. (2010)
1. Comment in: J.M.A. Oliveira and R.N. Lightowlers Could successful (mitochondrial) networking help prevent Huntington’s disease? EMBO Mol Med 2:487-9. (2010)
2. FFa 8 Faculty of1000 Medicine, S. Di Donato

L. Gomes, G. Di Benedetto and L. Scorrano During autophagy mitochondria elongate, are spared from degradation and sustain cell viability Nat. Cell. Biol. 13:589–598 (2011)
• Cover Article, Nat. Cell. Biol. 13 (5)
• Comment in: C. Blackstone and C.R. Chang Mitochondria unite to survive Nat. Cell. Biol. 13:521-2 (2011)
• Comment in: K. H. Wrighton Autophagy: Shaping the fate of mitochondria Nat. Rev. Mol. Cell Biol. 12:344-5 (2011)
• Comment in: L. Galluzzi, O. Kepp, and G. Kroemer Mitochondrial dynamics: a strategy for avoiding autophagy. Curr Biol. 21:R478-80 (2011).
• Editor’s Choice in: S.M. Hurtley Don’t Eat Me Science 332: 514-5 (2011).
• FFa 10 Faculty of1000 Biology, H. Osziewacz

S. Cogliati, C. Frezza, M.E. Soriano, T. Varanita, R. Quintana Cabrera, M. Corrado, S. Cipolat, V. Costa, A. Casarin, L.C. Gomes, E. Perales-Clemente, L. Salviati, P. Fernandez-Silva, and J.A. Enriquez, L. Scorrano. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell;155:160-71 (2013).
• Comment in: Stroud DA, Ryan MT. Mitochondria: Organization of Respiratory Chain Complexes Becomes Cristae-lized Curr Biol. (2013) 23:R969-71.

A. Kasahara, S. Cipolat, Y. Chen, and G.W. Dorn 2nd, L. Scorrano. Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science 342:734-7 (2013).
• Comment in: S. M. Hurtley, Mitochondrial Fusion and Heart Development. Sci. Signal. 6, ec277 (2013).
• FFa 10 Faculty of1000 Biology, H. Bellen/M. Sack

V Debattisti, D Pendin, E Ziviani, A Daga, and L. Scorrano. Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol. 204:303-12 (2014)
10. A Pyakurel, C. Savoia, D. Hess and L. Scorrano Extracellular regulated kinase phosphorylates Mitofusin 1 to control mitochondrial morphology and apoptosis. Mol. Cell, in the press (2015)